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RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells

24 Jun 2010

Abstract excerpt

INTRODUCTION: Paclitaxel is a widely used drug in the treatment of patients with locally advanced and metastatic breast cancer. However, only a small portion of patients have a complete response to paclitaxel-based chemotherapy, and many patients are resistant. Strategies that increase sensitivity and limit resistance to paclitaxel would be of clinical use, especially for patients with triple-negative breast...

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PMID: 20576088
DOI: 10.1186/bcr2595

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