Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability.

doi:10.1158/1078-0432.CCR-18-0504

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Article

Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2018

Yang Hailing, Mao Weiqun, Rodriguez-Aguayo Cristian, Mangala Lingegowda S, Bartholomeusz Geoffrey, Iles Lakesla R, Jennings Nicholas B, Ahmed Ahmed Ashour, Sood Anil K, Lopez-Berestein Gabriel, Lu Zhen, Bast Robert C

Abstract excerpt

Purpose: Most patients with ovarian cancer receive paclitaxel chemotherapy, but less than half respond. Pre-treatment microtubule stability correlates with paclitaxel response in ovarian cancer cell lines. Microtubule stability can be increased by depletion of individual kinases. As microtubule stability can be regulated by phosphorylation of microtubule-associated proteins (MAPs), we reasoned that depletion of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30084832
DOI: 10.1158/1078-0432.CCR-18-0504
PMCID: PMC6191368

Genes

EDN2
IKBKB
MAP4
STK39
TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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