Article
HLA-associated hemorrhagic fever with renal syndrome disease progression in slovenian patients.
Clinical and vaccine immunology : CVI - 1 Sept 2011
Korva Misa, Saksida Ana, Kunilo Sabina, Vidan Jeras Blanka, Avsic-Zupanc Tatjana
Abstract excerpt
Major histocompatibility complex (MHC) class I and class II genes regulate the balance between appropriate aggressive responses and invading pathogens while minimizing the destruction of host tissue. Several studies have shown that in hemorrhagic fever with renal syndrome (HFRS) patients, the disease outcome is determined by a complex interaction between the virus and immunopathologic and human genetic factors....
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