Article
Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population.
International journal of immunogenetics - 1 Aug 2009
Wang M L, Lai J H, Zhu Y, Zhang H B, Li C, Wang J P, Li Y M, Yang A G, Jin B Q
Abstract excerpt
We report a significantly higher occurrence of HLA-DRB1*09 (51% vs. 23%, P = 0.002, OR = 3.57) and HLA-B*46-DRB1*09 (26% vs. 8%, P = 0.018, OR = 3.76) in patients with haemorrhagic fever with renal syndrome (HFRS) compared to the control group, suggesting Hantaan virus-induced HFRS is associated with a genetic predisposition in the Chinese Han population.
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