Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Highly rapid and efficient conversion of human fibroblasts to keratinocyte-like cells.

The Journal of investigative dermatology - 1 Feb 2014

Chen Yifang, Mistry Devendra S, Sen George L

Abstract excerpt

Cell fate commitment during development is achieved through the expression of lineage-specific transcription factors. Recent studies have suggested that the expression of combinations of these lineage-specific transcription factors can convert adult somatic cells from one type to another. Here we report that the combination of p63, a master regulator of epidermal development and differentiation, and KLF4, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Fibroblasts
Share to HCT116 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Keratinocytes

Share to Kruppel-Like Factor 4

Share to Kruppel-Like Transcription Factors

Share to Positive Regulatory Domain I-Binding Factor 1

Share to Primary Cell Culture

Source

Open in PubMed Open full text

Identifiers

PMID: 23921950
DOI: 10.1038/jid.2013.327
PMCID: PMC3875612

Genes

KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Highly rapid and efficient conversion of human fibroblasts to keratinocyte-like cells.PMID 23921950Read ↗

Master regulatory role of p63 in epidermal development and disease.Semantic proximity Read ↗

Stagewise keratinocyte differentiation from human embryonic stem cells by defined signal transduction modulatorsSemantic proximity Read ↗

Increase developmental plasticity of human keratinocytes with gene suppressionSemantic proximity Read ↗

Human keratinocyte stem cells: From cell biology to cell therapySemantic proximity Read ↗

Induced multipotency in adult keratinocytes through down-regulation of <i>ΔNp63</i> or <i>DGCR8</i>Semantic proximity Read ↗

Reprogramming and Differentiation of Cutaneous Squamous Cell Carcinoma Cells in Recessive Dystrophic Epidermolysis Bullosa.Semantic proximity Read ↗

Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndromeSemantic proximity Read ↗

Mutant p53 subverts p63 control over KLF4 expression in keratinocytes.Semantic proximity Read ↗

Efficient and rapid generation of induced pluripotent stem cells from human keratinocytesSemantic proximity Read ↗

Long-term culture of skin biopsies: Maintenance of fibroblast production and competency of reprogrammingSemantic proximity Read ↗

Revisiting the significance of keratin expression in complex epitheliaSemantic proximity Read ↗

Single-cell RNA-seq identifies a reversible epithelial-mesenchymal transition in abnormally specified epithelia of p63 EEC syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.