Article

A quantitative systems pharmacology analysis of KRAS G12C covalent inhibitors

2017-06-21

Abstract excerpt

The KRAS oncogene is the most common, activating, oncogenic mutation in human cancer. KRAS has proven difficult to target effectively. Two different strategies have recently been described for covalently targeting the most common activating KRAS mutant in lung cancer, KRAS G12C. Previously, we have developed a computational model of the processes that regulate Ras activation and this model has proven useful for un...

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Literature Corpus work: ae2499ad-1718-5d50-8497-840d4ffbf29d
DOI: 10.1101/153635

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