Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A systems mechanism for KRAS mutant allele–specific responses to targeted therapy

24 Sept 2019

Abstract excerpt

cells remained dependent on EGFR for wild-type RAS activity. Overall, our work demonstrates how systems approaches enable mechanism-based inference in genomic medicine and can help identify patients for selective therapeutic strategies.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Cancer Treatments and Studies
Share to Enzyme Structure and Function
Share to HER2/EGFR in Cancer Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31551296
DOI: 10.1126/scisignal.aaw8288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A systems mechanism for KRAS mutant allele–specific responses to targeted therapyPMID 31551296Read ↗

A quantitative systems pharmacology analysis of KRAS G12C covalent inhibitorsSemantic proximity Read ↗

Quantitative Systems Pharmacology Analysis of KRAS G12C Covalent Inhibitors.Semantic proximity Read ↗

What lies beneath: looking beyond tumor genetics shows the complexity of signaling networks underlying drug sensitivity.Semantic proximity Read ↗

A Nexus between Genetic and Non-Genetic Mechanisms Guides KRAS Inhibitor Resistance in Lung Cancer.Semantic proximity Read ↗

Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach.Semantic proximity Read ↗

Changes in the Transcriptome and Synthetic Lethal Dependencies Following <i>KRAS</i> Mutant Expression Reveal Profound Tissue-SpecificitySemantic proximity Read ↗

Mathematical Modeling to Study KRAS Mutant-Specific Responses to Pathway Inhibition.Semantic proximity Read ↗

The origins and genetic interactions of KRAS mutations are allele- and tissue-specific.Semantic proximity Read ↗

New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling.Semantic proximity Read ↗

Sweeping KRAS generalizations: are we depriving patients of an effective treatment? A novel KRAS mutation and dramatic response to panitumumab in a patient with metastatic colorectal cancer.Semantic proximity Read ↗

Modeling RAS Phenotype in Colorectal Cancer Uncovers Novel Molecular Traits of RAS Dependency and Improves Prediction of Response to Targeted Agents in PatientsSemantic proximity Read ↗

KRASG12C inhibition produces a driver-limited state revealing collateral dependencies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.