Article
Crystal structure of human ISG15 protein in complex with influenza B virus NS1B.
The Journal of biological chemistry - 2 Sept 2011
Li Liang, Wang Dongli, Jiang Yinan, Sun Jianfeng, Zhang Senyan, Chen Yuanyuan, Wang Xinquan
Abstract excerpt
ISG15 (interferon-stimulated gene 15), the first ubiquitin-like protein (UBL) identified, has emerged as an important cellular antiviral factor. It consists of two UBL domains with a short linker between them. The covalent attachment of ISG15 to host and viral proteins to modify their functions, similar to ubiquitylation, is named ISGylation. Influenza B virus NS1B protein antagonizes human but not mouse...
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