Article
Controllable expansion of primary cardiomyocytes by reversible immortalization.
Human gene therapy - 1 Dec 2009
Zhang Yue, Nuglozeh Edem, Touré Fatouma, Schmidt Ann Marie, Vunjak-Novakovic Gordana
Abstract excerpt
Cardiac tissue engineering will remain only a prospect unless large numbers of therapeutic cells can be provided, either from small samples of cardiac cells or from stem cell sources. In contrast to most adult cells, cardiomyocytes are terminally differentiated and cannot be expanded in culture. We explored the feasibility of enabling the in vitro expansion of primary neonatal rat cardiomyocytes by...
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