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Article

Cell-Type-Specific Type I Interferon Antagonism Influences Organ Tropism of Murine Coronavirus

14 Jul 2011

Abstract excerpt

Previous studies have demonstrated that mouse hepatitis virus (MHV) hepatotropism is determined largely by postentry events rather than by availability of the viral receptor. In addition, mutation of MHV nonstructural protein 2 (ns2) abrogates the ability of the virus to replicate in the liver and induce hepatitis but does not affect replication in the central nervous system (CNS). Here we show that replication...

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PMID: 21752905
DOI: 10.1128/jvi.05075-11

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