Article
Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia.
Schizophrenia research - 1 Sept 2011
Chen Jingchun, Lee Grace, Fanous Ayman H, Zhao Zhongming, Jia Peilin, O'Neill Anthony, Walsh Dermot, Kendler Kenneth S, Chen Xiangning
Abstract excerpt
We conducted data-mining analyses of genome wide association (GWA) studies of the CATIE and MGS-GAIN datasets, and found 13 markers in the two physically linked genes, PTPN21 and EML5, showing nominally significant association with schizophrenia. Linkage disequilibrium (LD) analysis indicated that all 7 markers from PTPN21 shared high LD (r(2)>0.8), including rs2274736 and rs2401751, the two non-synonymous...
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