Article
Quantitative phosphoproteomics reveals link between <i>Helicobacter pylori</i> infection and RNA splicing modulation in host cells
4 May 2011
Abstract excerpt
The Gram-negative, spiral-shaped bacterium Helicobacter pylori is a common human pathogen that causes chronic inflammation of the human gastric mucosa, leading to peptic ulceration and/or gastric cancer. Here, we analyzed changes in the phosphoproteome of gastric epithelial cells (AGS) upon infection with H. pylori using a combination of SILAC, phosphoprotein enrichment, 2-DE, and MALDI TOF/TOF-MS. From a total...
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