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Mechanism of 150-cavity formation in influenza neuraminidase

12 Jul 2011

Abstract excerpt

The recently discovered 150-cavity in the active site of group-1 influenza A neuraminidase (NA) proteins provides a target for rational structure-based drug development to counter the increasing frequency of antiviral resistance in influenza. Surprisingly, the 2009 H1N1 pandemic virus (09N1) neuramidase was crystalized without the 150-cavity characteristic of group-1 NAs. Here we demonstrate, through a total sum...

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PMID: 21750542
DOI: 10.1038/ncomms1390

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