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Article

Mutation-induced loop opening and energetics for binding of tamiflu to influenza N8 neuraminidase.

The journal of physical chemistry. B - 31 May 2012

Kar Parimal, Knecht Volker

Abstract excerpt

Tamiflu, also known as oseltamivir (OTV), binds to influenza A neuraminidase (H5N1) with very high affinity (0.32 nM). However, this inhibitor binds to other neuraminidases as well. In the present work, a systematic computational study is performed to investigate the mechanism underlying the bind...

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Source

Identifiers

PMID: 22553951
DOI: 10.1021/jp3022612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22553951-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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