Article
Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Sept 2008
Ferguson L R, Browning B L, Huebner C, Petermann I, Shelling A N, Demmers P, McCulloch A, Gearry R B, Barclay M L, Philpott M
Abstract excerpt
BACKGROUND: Human Paneth cell alpha-defensins, especially DEFA5, are involved in maintaining homeostasis of the human microbial microflora. Since breakdown of normal mucosal antibacterial defence occurs in inflammatory bowel disease (IBD), variants in the DEFA5 gene could be associated with IBD risk. SUBJECTS: A cohort of 25 patients with indeterminate colitis (IC), 405 with ulcerative colitis (UC), and 385 with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.