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Article

High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1.

Genes, chromosomes & cancer - 1 Oct 2011

Karlsson Elin, Waltersson Marie Ahnström, Bostner Josefine, Pérez-Tenorio Gizeh, Olsson Birgit, Hallbeck Anna-Lotta, Stål Olle

Abstract excerpt

The chromosomal region 11q13 is amplified in 15-20% of breast cancers; an event not only associated with estrogen receptor (ER) expression but also implicated in resistance to endocrine therapy. Coamplifications of the 11q13 and 8p12 regions are common, suggesting synergy between the amplicons. The aim was to identify candidate oncogenes in the 11q13 region based on recurrent amplification patterns and...

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Share to Chromosomes, Human, Pair 11
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21748818
DOI: 10.1002/gcc.20900

Genes

CCND1
FGFR1
FGF19
FGF3
FGF4
GAB2
PAK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1.PMID 21748818Read ↗

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