Genetic and functional evidence implicating DLL1 as the gene that influences susceptibility to visceral leishmaniasis at chromosome 6q27.

doi:10.1093/infdis/jir284

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Article

Genetic and functional evidence implicating DLL1 as the gene that influences susceptibility to visceral leishmaniasis at chromosome 6q27.

The Journal of infectious diseases - 1 Aug 2011

Fakiola Michaela, Miller E Nancy, Fadl Manal, Mohamed Hiba S, Jamieson Sarra E, Francis Richard W, Cordell Heather J, Peacock Christopher S, Raju Madhuri, Khalil Eltahir A, Elhassan Ahmed, Musa Ahmed M, Silveira Fernando, Shaw Jeffrey J, Sundar Shyam, Jeronimo Selma M B, Ibrahim Muntaser E, Blackwell Jenefer M

Abstract excerpt

BACKGROUND: Visceral leishmaniasis (VL) is caused by Leishmania donovani and Leishmania infantum chagasi. Genome-wide linkage studies from Sudan and Brazil identified a putative susceptibility locus on chromosome 6q27. METHODS: Twenty-two single-nucleotide polymorphisms (SNPs) at genes PHF10, C6orf70, DLL1, FAM120B, PSMB1, and TBP were genotyped in 193 VL cases from 85 Sudanese families, and 8 SNPs at genes...

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Identifiers

PMID: 21742847
DOI: 10.1093/infdis/jir284
PMCID: PMC3132144

Genes

DLL1
PHF10
PSMB1
TBP

Provenance

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