Article
IL28B genotype effects during early treatment with peginterferon and ribavirin in difficult-to-treat hepatitis C virus infection.
The Journal of infectious diseases - 1 Aug 2011
Scott John, Holte Sarah, Urban Thomas, Burgess Caitlin, Coppel Erica, Wang Chia, Corey Larry, McHutchison John, Goldstein David
Abstract excerpt
BACKGROUND: Mathematical models of hepatitis C virus (HCV) during therapy may elucidate mechanisms of action for antiviral therapy. In genome-wide association studies, IL28B gene polymorphisms are highly predictive of therapeutic clearance of HCV. METHODS: We collected sera from 20 chronically infected HCV participants at 13 points during the first 28 days of therapy. We assessed the presence of the C allele at...
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