Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ultra-deep pyrosequencing analysis of the hepatitis B virus preCore region and main catalytic motif of the viral polymerase in the same viral genome.

Nucleic acids research - 1 Oct 2011

Homs Maria, Buti Maria, Quer Josep, Jardí Rosendo, Schaper Melanie, Tabernero David, Ortega Israel, Sanchez Alex, Esteban Rafael, Rodriguez-Frias Francisco

Abstract excerpt

Hepatitis B virus (HBV) pregenomic RNA contains a hairpin structure (ε) located in the preCore region, essential for viral replication. ε stability is enhanced by the presence of preCore variants and ε is recognized by the HBV polymerase (Pol). Mutations in the retrotranscriptase domain (YMDD) of Pol are associated with treatment resistance. The aim of this study was to analyze the preCore region and YMDD motif...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pairing
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deoxyribonuclease HindIII

Share to Gene Products, pol

Share to Hepatitis B virus

Share to Nucleic Acid Conformation

Share to Viral Regulatory and Accessory Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21742757
DOI: 10.1093/nar/gkr451
PMCID: PMC3201856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ultra-deep pyrosequencing analysis of the hepatitis B virus preCore region and main catalytic motif of the viral polymerase in the same viral genome.PMID 21742757Read ↗

Analysis of ultra-deep pyrosequencing and cloning based sequencing of the basic core promoter/precore/core region of hepatitis B virus using newly developed bioinformatics tools.Semantic proximity Read ↗

A comparative study of ultra-deep pyrosequencing and cloning to quantitatively analyze the viral quasispecies using hepatitis B virus infection as a model.Semantic proximity Read ↗

Quasispecies dynamics in main core epitopes of hepatitis B virus by ultra-deep-pyrosequencing.Semantic proximity Read ↗

Ultradeep pyrosequencing and molecular modeling identify key structural features of hepatitis B virus RNase H, a putative target for antiviral intervention.Semantic proximity Read ↗

Ultra-deep pyrosequencing (UDPS) data treatment to study amplicon HCV minor variants.Semantic proximity Read ↗

Whole genome characterization of hepatitis B virus quasispecies with massively parallel pyrosequencing.Semantic proximity Read ↗

Pyrosequencing for discovery and analysis of DNA sequence variations.Semantic proximity Read ↗

Minor variant detection in amplicons using 454 massive parallel pyrosequencing: experiences and considerations for successful applications.Semantic proximity Read ↗

Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients.Semantic proximity Read ↗

A high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection.Semantic proximity Read ↗

Pyrosequencing technology and the need for versatile solutions in molecular clinical research.Semantic proximity Read ↗

Comparison of Basal Core Promoter Region Mutation and Precore Mutation among Monoinfected Hepatitis B Virus and Coinfected Hepatitis B Virus with Human Immunodeficiency Virus Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.