Article

Alternative Splicing Directs PMCA2 to Lysosomes and is Linked to Neurodegeneration

2025-10-02

Abstract excerpt

Plasma membrane calcium ATPases (PMCAs) are believed to function exclusively at the plasma membrane where they expel calcium from the cytosol. We have unexpectedly identified a splice variant-dependent localisation of the PMCA isoform PMCA2 to the lysosome, where it forms an evolutionarily conserved complex with NPC1, the lysosomal membrane protein defective in the rare lysosomal storage disease Niemann-Pick disea...

Identifiers and source

Literature Corpus work: 733ec776-decd-52cc-9dfc-3878dde09f35
DOI: 10.1101/2025.10.01.679724

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