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Article

Epigenetic Activation of SOX11 in Lymphoid Neoplasms by Histone Modifications

27 Jun 2011

Abstract excerpt

Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in stem cells, normal hematopoietic cells and different lymphoid neoplasms. We observed that SOX11 expression is associated with unmethylated DNA and presence of activating...

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PMID: 21738649
DOI: 10.1371/journal.pone.0021382

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