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A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology

18 Aug 2023

Abstract excerpt

Blood cells contain functionally important intracellular structures, such as granules, critical to immunity and thrombosis. Quantitative variation in these structures has not been subjected previously to large-scale genetic analysis. We perform genome-wide association studies of 63 flow-cytometry derived cellular phenotypes-including cell-type specific measures of granularity, nucleic acid content and...

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PMID: 37596262
DOI: 10.1038/s41467-023-40679-y

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