Article
Association of two glyoxalase I gene polymorphisms with nephropathy and retinopathy in Type 2 diabetes.
Journal of endocrinological investigation - 1 Nov 2011
Wu J C, Li X H, Peng Y D, Wang J B, Tang J F, Wang Y F
Abstract excerpt
BACKGROUND: Glyoxalase I (GLO1), which is the major enzyme that catalyzes the metabolism of methylglyoxal (MG), may play an important role in the pathogenesis of diabetic microvascular complications. AIM: To investigate whether the C-7T and A419C polymorphisms of the GLO1 gene are associated with nephropathy and retinopathy in Chinese Type 2 diabetic patients. SUBJECTS AND METHODS: A total of 364 Type 2 diabetic...
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