Article
Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology - 1 May 2004
Boucher Marie-Josée, Jean Dominique, Vézina Anne, Rivard Nathalie
Abstract excerpt
The mitogen-activated protein kinase cascade operates downstream of Ras to convey cell-surface signals to the nucleus via nuclear translocation of ERK1 and ERK2. We and others have recently demonstrated that activation of ERK1/2 by growth factors is required for proliferation of intestinal epithelial crypt cells. However, it remained to be established whether ERK1/2 activation alone was sufficient to trigger...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.