Article
Association of mannose-binding lectin-2 gene polymorphism with the development of hepatitis C-induced hepatocellular carcinoma.
Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2011
Eurich Dennis, Boas-Knoop Sabine, Morawietz Lars, Neuhaus Ruth, Somasundaram Rajan, Ruehl Martin, Neumann Ulf P, Neuhaus Peter, Bahra Marcus, Seehofer Daniel
Abstract excerpt
BACKGROUND: Development of end-stage liver and graft disease is suspected to be partially determined by the individual genetic background. Mannose-binding lectin (MBL) is an important immunomodulatory factor, which is supposed to be involved in complement activation and oncogenesis. Genetic polymorphisms of MBL-2 alter MBL functionality. The aim of our study was to determine the prevalence of MBL-2 polymorphism...
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