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Article

Genetic evidence for involvement of classical complement pathway in induction of experimental autoimmune myasthenia gravis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2003

Tüzün Erdem, Scott Benjamin G, Goluszko Elzbieta, Higgs Stephen, Christadoss Premkumar

Abstract excerpt

Abs to acetylcholine receptor (AChR) and complement are the major constituents of pathogenic events causing neuromuscular junction destruction in both myasthenia gravis (MG) and experimental autoimmune MG (EAMG). To analyze the differential roles of the classical vs alternative complement pathways in EAMG induction, we immunized C3(-/-), C4(-/-), C3(+/-), and C4(+/-) mice and their control littermates (C3(+/+)...

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Identifiers

PMID: 14500686
DOI: 10.4049/jimmunol.171.7.3847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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