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Article

Decomposing Dynamical Couplings in Mutated scFv Antibody Fragments into Stabilizing and Destabilizing Effects.

Journal of the American Chemical Society - 6 Dec 2017

Ettayapuram Ramaprasad Azhagiya Singam, Uddin Shahid, Casas-Finet Jose, Jacobs Donald J

Abstract excerpt

Conformational fluctuations within scFv antibodies are characterized by a novel perturbation-response decomposition of molecular dynamics trajectories. Both perturbation and response profiles are stratified into stabilizing and destabilizing conditions. The linker between the VH and VL domains exhibits the dominant dynamical response by being coupled to nearly the entire protein, responding to both stabilizing...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complementarity Determining Regions

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Source

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Identifiers

PMID: 29139290
DOI: 10.1021/jacs.7b09268
PMCID: PMC5998336

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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