Article

ESTROGEN IMPACTS NOD2-DEPENDENT REGULATION OF INTESTINAL HOMEOSTASIS

2025-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the innate immune receptor NOD2 are the greatest single genetic risk factor for Crohn’s disease, yet the mechanisms by which NOD2 regulates intestinal homeostasis remain unclear. We used a CRISPR-generated zebrafish model to determine the impacts of NOD2 deficiency on intestinal health. In cellular, molecular, and transcriptomic studies, we uncovered substantial effects of NOD2 defi...

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Literature Corpus work: 7c84e0cb-1932-5014-9fe6-5e35b529a597
DOI: 10.1101/2025.07.04.663219

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