Article
A novel pathway determining multidrug sensitivity in Schizosaccharomyces pombe.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Oct 2005
Thornton Gemma, Wilkinson Caroline R M, Toone W Mark, Jones Nic
Abstract excerpt
In this study, we show that a mutation isolated during a screen for determinants of chemosensitivity in S. pombe results in loss of function of a previously uncharacterized protein kinase now named Hal4. Hal4 shares sequence homology to Hal4 and Hal5 in S. cerevisiae, and previous evidence indicates that these kinases positively regulate the major potassium transporter Trk1,2 and thereby maintain the plasma...
Topics
- Cation Transport Proteins
- Cations
- Cell Membrane
- Dose-Response Relationship, Drug
- Drug Resistance, Multiple, Fungal
- Escherichia coli
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Membrane Potentials
- Mutation
- Potassium Chloride
- Protein Kinases
- Protein Serine-Threonine Kinases
- Saccharomyces cerevisiae Proteins
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Sequence Homology