A novel approach to exploring potential interactions among single-nucleotide polymorphisms of inflammation genes in gliomagenesis: an exploratory case-only study.

doi:10.1158/1055-9965.EPI-11-0203

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Article

A novel approach to exploring potential interactions among single-nucleotide polymorphisms of inflammation genes in gliomagenesis: an exploratory case-only study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2011

Amirian E Susan, Scheurer Michael E, Liu Yanhong, D'Amelio Anthony M, Houlston Richard S, Etzel Carol J, Shete Sanjay, Swerdlow Anthony J, Schoemaker Minouk J, McKinney Patricia A, Fleming Sarah J, Muir Kenneth R, Lophatananon Artitaya, Bondy Melissa L

Abstract excerpt

BACKGROUND: Despite extensive research on the topic, glioma etiology remains largely unknown. Exploration of potential interactions between single-nucleotide polymorphisms (SNP) of immune genes is a promising new area of glioma research. The case-only study design is a powerful and efficient design for exploring possible multiplicative interactions between factors that are independent of one another. The purpose...

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PMID: 21724854
DOI: 10.1158/1055-9965.EPI-11-0203
PMCID: PMC3904785

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