pH 2 instability of a mutant of mengovirus is related to its interferon sensitivity.

Abstract excerpt

The is-1 mutant of mengovirus is 100 times more sensitive to interferon (IFN) than wild type, as measured by a yield reduction assay in the G3 line of mouse L cells, and is also much more readily inactivated at pH 2. Neither isolated nor encapsidated RNA is degraded under these conditions, which suggests that the pH-sensitive region resides on the virus coat. One-third of the viruses selected for resistance to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Electrophoresis, Gel, Two-Dimensional
• Share to Hot Temperature
• Share to Hydrogen-Ion Concentration