Article
pH 2 instability of a mutant of mengovirus is related to its interferon sensitivity.
Journal of interferon research - 1 Aug 1990
Bakich E A, Monahan S J, Simon E H
Abstract excerpt
The is-1 mutant of mengovirus is 100 times more sensitive to interferon (IFN) than wild type, as measured by a yield reduction assay in the G3 line of mouse L cells, and is also much more readily inactivated at pH 2. Neither isolated nor encapsidated RNA is degraded under these conditions, which suggests that the pH-sensitive region resides on the virus coat. One-third of the viruses selected for resistance to...
Topics
- Electrophoresis, Gel, Two-Dimensional
- Hot Temperature
- Hydrogen-Ion Concentration
- Interferon Type I
- Mengovirus
- Mutation
- RNA, Viral
- Sulfur Radioisotopes
- Viral Structural Proteins