Low pH-induced cytopathic effect--a survey of seven hantavirus strains.

doi:10.1016/s0166-0934(99)00042-7

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Article

Low pH-induced cytopathic effect--a survey of seven hantavirus strains.

Journal of virological methods - 1 Aug 1999

McCaughey C, Shi X, Elliot R M, Wyatt D E, O'Neill H J, Coyle P V

Abstract excerpt

Hantaviruses do not produce cytopathic effects (CPE) in cell culture. However, a syncytial CPE can be induced in 7-day cultures of hantavirus growing in Vero E6 cells by reduction of the pH to approximately 6.2 using a HEPES based buffer. The appearance of this acid induced CPE was examined for seven different hantavirus strains. The differences noted were striking and reflected the taxonomic differences between...

Topics

Animals
Chlorocebus aethiops
Cytopathogenic Effect, Viral
Giant Cells
Orthohantavirus
Humans
Hydrogen-Ion Concentration
Phenotype
Rats
Vero Cells

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Open in PubMed

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PMID: 10488778
DOI: 10.1016/s0166-0934(99)00042-7

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