Article
Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors.
Gastroenterology - 1 Feb 2014
Marinoni Ilaria, Kurrer Anja Schmitt, Vassella Erik, Dettmer Matthias, Rudolph Thomas, Banz Vanessa, Hunger Fabio, Pasquinelli Silvan, Speel Ernst-Jan, Perren Aurel
Abstract excerpt
BACKGROUND & AIMS: Sporadic pancreatic neuroendocrine tumors (pNETs) are rare and genetically heterogeneous. Chromosome instability (CIN) has been detected in pNETs from patients with poor outcomes, but no specific genetic factors have been associated with CIN. Mutations in death domain-associated protein gene (DAXX) or ATR-X gene (ATRX) (which both encode proteins involved in chromatin remodeling) have been...
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