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Article

The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.

Journal of virology - 1 Jun 1990

Heilbronn R, Bürkle A, Stephan S, zur Hausen H

Abstract excerpt

Herpes simplex virus (HSV) induces within the host cell genome DNA amplification which can be suppressed by coinfection with adeno-associated virus (AAV). To characterize the AAV functions mediating this effect, cloned AAV type 2 wild-type or mutant genomes were transfected into simian virus 40 (SV40)-transformed hamster cells together with the six HSV replication genes (encoding UL5, UL8, major DNA-binding...

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Identifiers

PMID: 2159559
DOI: 10.1128/JVI.64.6.3012-3018.1990
PMCID: PMC249485

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.PMID 2159559Read ↗

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The Rep Protein of Adeno-Associated Virus Type 2 Interacts with Single-Stranded DNA-Binding Proteins That Enhance Viral ReplicationSemantic proximity Read ↗

Modulation of the cellular phenotype by integrated adeno-associated virus.Semantic proximity Read ↗

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Inhibition of cellular and SV40 DNA replication by the adeno-associated virus Rep proteins.Semantic proximity Read ↗

A subset of herpes simplex virus replication genes provides helper functions for productive adeno-associated virus replication.Semantic proximity Read ↗

Expression of AAV Rep proteins in SV40-transformed and untransformed cells: reciprocal interaction with host DNA synthesis.Semantic proximity Read ↗

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