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Article

The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.

Journal of virology - 1 Jun 1990

Heilbronn R, Bürkle A, Stephan S, zur Hausen H

Abstract excerpt

Herpes simplex virus (HSV) induces within the host cell genome DNA amplification which can be suppressed by coinfection with adeno-associated virus (AAV). To characterize the AAV functions mediating this effect, cloned AAV type 2 wild-type or mutant genomes were transfected into simian virus 40 (SV40)-transformed hamster cells together with the six HSV replication genes (encoding UL5, UL8, major DNA-binding...

Topics

Cell Line
Cell Transformation, Viral
Cloning, Molecular
DNA Replication
Dependovirus
Gene Amplification
Genes, Viral
HeLa Cells
Helper Viruses
Humans
Mutation
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Simplexvirus

Suppression, Genetic

Transfection

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 2159559
DOI: 10.1128/JVI.64.6.3012-3018.1990
PMCID: PMC249485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2159559-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.PMID 2159559Read ↗

Definition of Herpes Simplex Virus Type 1 Helper Activities for Adeno-Associated Virus Early Replication EventsSemantic proximity Read ↗

Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and CapSemantic proximity Read ↗

The Rep Protein of Adeno-Associated Virus Type 2 Interacts with Single-Stranded DNA-Binding Proteins That Enhance Viral ReplicationSemantic proximity Read ↗

Modulation of the cellular phenotype by integrated adeno-associated virus.Semantic proximity Read ↗

Herpes simplex virus type 1 mutants for the origin-binding protein induce DNA amplification in the absence of viral replication.Semantic proximity Read ↗

Inhibition of cellular and SV40 DNA replication by the adeno-associated virus Rep proteins.Semantic proximity Read ↗

A subset of herpes simplex virus replication genes provides helper functions for productive adeno-associated virus replication.Semantic proximity Read ↗

Expression of AAV Rep proteins in SV40-transformed and untransformed cells: reciprocal interaction with host DNA synthesis.Semantic proximity Read ↗

Adeno-Associated Virus Rep78 Protein Interacts with Protein Kinase A and Its Homolog PRKX and Inhibits CREB-Dependent Transcriptional ActivationSemantic proximity Read ↗

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High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and CapSemantic proximity Read ↗

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