Article
Large-scale production of the immunomodulator c-di-GMP from GMP and ATP by an enzymatic cascade.
Applied biochemistry and biotechnology - 1 Oct 2011
Spehr Volker, Warrass Ralf, Höcherl Klaus, Ilg Thomas
Abstract excerpt
(3'-5')-Cyclic diguanylate (c-di-GMP) is a bacterial second messenger with immunomodulatory activities in mice suggesting potential applications as a vaccine adjuvant and as a therapeutic agent. Clinical studies in larger animals or humans will require larger doses that are difficult and expensive to generate by currently available chemical or enzymatic synthesis and purification methods. Here we report the...
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