Article
Impact of HIV type 1 subtype on drug resistance mutations in Nigerian patients failing first-line therapy.
AIDS research and human retroviruses - 1 Jan 2011
Chaplin B, Eisen G, Idoko J, Onwujekwe D, Idigbe E, Adewole I, Gashau W, Meloni S, Sarr A D, Sankalé J L, Ekong E, Murphy R L, Kanki P
Abstract excerpt
A diverse array of non-subtype B HIV-1 viruses circulates in Africa and dominates the global pandemic. It is important to understand how drug resistance mutations in non-B subtypes may develop differently from the patterns described in subtype B. HIV-1 reverse transcriptase and protease sequences from 338 patients with treatment failure to first-line ART regimens were evaluated. Multivariate logistic regression...
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