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Article

Interleukin-17A is involved in development of spontaneous pulmonary emphysema caused by Toll-like receptor 4 mutation.

Acta pharmacologica Sinica - 1 Aug 2011

Wang Qing-qing, Yang Hong-zhen, Liu Han-zhi, Mi Su, Zhang Xiao-wei, Yan Hui-min, Ma Yong-gang, Wang Xiao-xing, Hu Zhuo-wei

Abstract excerpt

AIM: To explore the pathogenic role of Th17 cells and interleukin-17A (IL-17A)-associated signaling pathways in spontaneous pulmonary emphysema induced by a Toll-like receptor 4 mutant (TLR4(mut)). METHODS: Lungs were obtained from wild-type (WT) or TLR4mut mice that were treated with or without recombinant mouse IL-17A (1 μg·kg(-1)·d(-1), ip) from the age of 3 weeks to 3 months. Pulmonary emphysema was...

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Identifiers

PMID: 21706041
DOI: 10.1038/aps.2011.67
PMCID: PMC4002530

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TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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