Article
Toll-Like Receptor–Mediated Airway IL-17C Enhances Epithelial Host Defense in an Autocrine/Paracrine Manner
14 Aug 2013
Abstract excerpt
IL-17A, IL-17F, and IL-25 belong to the IL-17 family of cytokines, and are well known to play important roles in the host defense against infection and inflammatory diseases. IL-17C, also a member of the IL-17 family, is highly expressed in the epithelium; however, the function and regulatory mechanism of IL-17C in airway epithelium remain poorly understood. In this study, we demonstrate that...
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