Article
Reduced expression of PHD2 prolyl hydroxylase gene in primary advanced uterine cervical carcinoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jul 2011
Roszak Andrzej, Kędzia Witold, Malkowska-Walczak Blanka, Pawlik Piotr, Kędzia Helena, Łuczak Michał, Lianeri Margarita, Jagodzinski Paweł P
Abstract excerpt
Decreased PHD2 expression in human carcinomas has been considered a critical factor in supporting tumor angiogenesis and growth. We studied the levels of PHD2 transcript and protein in advanced cervical cancer specimens (n=27) and normal uterine cervical tissue samples (n=27). Real-time quantitative PCR and Western blotting analysis showed significantly lower levels of PHD2 transcript (P=0.0088) and protein...
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