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Article

Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth.

Experimental cell research - 15 Apr 2010

Jokilehto Terhi, Högel Heidi, Heikkinen Pekka, Rantanen Krista, Elenius Klaus, Sundström Jari, Jaakkola Panu M

Abstract excerpt

Cellular oxygen tension is sensed by a family of prolyl hydroxylases (PHD1-3) that regulate the degradation of hypoxia-inducible factors (HIF-1alpha and -2alpha). The PHD2 isoform is considered as the main downregulator of HIF in normoxia. Our previous results have shown that nuclear translocatio...

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Identifiers

PMID: 20156434
DOI: 10.1016/j.yexcr.2010.02.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20156434-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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