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Article

Functional characterization of recurrent FOXA2 mutations seen in endometrial cancers.

International journal of cancer - 1 Dec 2018

Neff Robert, Rush Craig M, Smith Blair, Backes Floor J, Cohn David E, Goodfellow Paul J

Abstract excerpt

FOXA2, a member of the forkhead family of DNA-binding proteins, is frequently mutated in uterine cancers. Most of the mutations observed in uterine cancers are frameshifts and stops. FOXA2 is considered to be a driver gene in uterine cancers, functioning as a haploinsufficient tumor suppressor. The functional consequences of FOXA2 mutations, however, have not yet been determined. We evaluated the effects that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30091462
DOI: 10.1002/ijc.31784
PMCID: PMC6235715

Genes

FOXA2
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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