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Article

Restriction enzyme-mediated enhanced detection of circulating cell-free fetal DNA in maternal plasma.

The Journal of molecular diagnostics : JMD - 1 Jul 2011

Tynan John A, Mahboubi Payam, Cagasan Lesley L, van den Boom Dirk, Ehrich Mathias, Oeth Paul

Abstract excerpt

A universal method confirming the presence of circulating cell-free fetal (ccff) DNA in maternal plasma is important in the field of noninvasive prenatal diagnostics. Restriction endonuclease digestion of one allele of a single-nucleotide polymorphism (SNP) was used to allow detection of paternal alleles in maternal plasma DNA. Multiplexed genotyping of 92 panethnic high-frequency SNPs predicted >0.99 probability...

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Identifiers

PMID: 21704271
DOI: 10.1016/j.jmoldx.2011.02.001
PMCID: PMC3123783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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