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Quantification of Fetal DNA by Use of Methylation-Based DNA Discrimination

21 Aug 2010

Abstract excerpt

BACKGROUND: Detection of circulating cell-free fetal nucleic acids in maternal plasma has been used in noninvasive prenatal diagnostics. Most applications rely on the qualitative detection of fetal nucleic acids to determine the genetic makeup of the fetus. This method leads to an analytic dilemma, because test results from samples that do not contain fetal DNA or are contaminated with maternal cellular DNA can...

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PMID: 20729299
DOI: 10.1373/clinchem.2010.146290

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