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High-Quality SNP Array Genotyping from Ultralow Quantities of Maternal Plasma Cell-Free DNA During Pregnancy

2026-07-23

Abstract excerpt

<title>Abstract</title> <p>Genome-wide SNP-array genotyping of maternal plasma cell-free-DNA (cfDNA) could extend applications of non-invasive prenatal testing, but low cfDNA quantity may limit performance. This study evaluated minimum amounts of genomic-DNA (gDNA) and cfDNA required for successful genotyping during pregnancy. Thirty healthy pregnant women from the Newcastle 1000 Study were recruited. gDNA and cf...

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Literature Corpus work: 26b004fa-ea1f-5e72-bca4-683ba5d6e6d4
DOI: 10.21203/rs.3.rs-10262698/v1

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