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Article

In vitro selection and characterization of HCV replicons resistant to multiple non-nucleoside polymerase inhibitors.

Journal of hepatology - 1 Jan 2012

Delang Leen, Vliegen Inge, Leyssen Pieter, Neyts Johan

Abstract excerpt

BACKGROUND & AIMS: To delay or prevent the selection of HCV drug-resistant variants, combination therapy will be needed. Our aim was to determine the antiviral efficacy of various combinations of non-nucleoside polymerase inhibitors (NNI) (that have a different allosteric binding site) and the barrier towards resistance development of such combinations. METHODS: Short-term antiviral combination assays were...

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Share to Allosteric Site
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Share to Drug Resistance, Multiple, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21703175
DOI: 10.1016/j.jhep.2011.04.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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