Article
African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans.
Human molecular genetics - 1 May 2010
Behar Doron M, Rosset Saharon, Tzur Shay, Selig Sara, Yudkovsky Guennady, Bercovici Sivan, Kopp Jeffrey B, Winkler Cheryl A, Nelson George W, Wasser Walter G, Skorecki Karl
Abstract excerpt
Recent studies identified MYH9 as a major susceptibility gene for common forms of non-diabetic end-stage kidney disease (ESKD). A set of African ancestry DNA sequence variants comprising the E-1 haplotype, was significantly associated with ESKD. In order to determine whether African ancestry variants are also associated with disease susceptibility in admixed populations with differing genomic backgrounds, we...
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