Article
Unnecessary antiretroviral treatment switches and accumulation of HIV resistance mutations; two arguments for viral load monitoring in Africa.
Journal of acquired immune deficiency syndromes (1999) - 1 Sept 2011
Sigaloff Kim C E, Hamers Raph L, Wallis Carole L, Kityo Cissy, Siwale Margaret, Ive Prudence, Botes Mariette E, Mandaliya Kishor, Wellington Maureen, Osibogun Akin, Stevens Wendy S, van Vugt Michèle, de Wit Tobias F Rinke
Abstract excerpt
OBJECTIVES: This study aimed to investigate the consequences of using clinicoimmunological criteria to detect antiretroviral treatment (ART) failure and guide regimen switches in HIV-infected adults in sub-Saharan Africa. Frequencies of unnecessary switches, patterns of HIV drug resistance, and risk factors for the accumulation of nucleoside reverse transcriptase inhibitor (NRTI)-associated mutations were...
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