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Article

Multiplex ligation-dependent probe amplification of conjunctival melanoma reveals common BRAF V600E gene mutation and gene copy number changes.

Investigative ophthalmology & visual science - 29 Jul 2011

Lake Sarah L, Jmor Fidan, Dopierala Justyna, Taktak Azzam F G, Coupland Sarah E, Damato Bertil E

Abstract excerpt

PURPOSE: To determine the occurrence of BRAF V600E gene mutations and copy number changes of all autosome arms and genes known to be frequently altered in tumorigenesis in primary and metastatic conjunctival melanomas (CoMs). METHODS: DNA (200 ng) was analyzed by three multiplex ligation-dependent probe amplification assays (P027 uveal melanoma, P036 human telomere, and P206 spitzoid melanoma). RESULTS: Eight of...

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Source

Identifiers

PMID: 21693616
DOI: 10.1167/iovs.10-6934

Genes

BRAF
RUNX2
ECHS1
MGMT
MLH1
TIMP2
OPRL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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