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Article

Biochemical properties and in vivo effects of the SOD1 zinc-binding site mutant (H80G).

Journal of neurochemistry - 1 Sept 2011

Son Marjatta, Srikanth Uma, Puttaparthi Krishna, Luther Christina, Elliott Jeffrey L

Abstract excerpt

This study presents the initial characterization of transgenic mice with mutations in a primary zinc-binding residue (H80), either alone or with a G93A mutation. H80G;G93A superoxide dismutase 1 (SOD1) transgenic mice developed paralysis with motor neuron loss, and ubiquitin inclusion-type rather than mitochondrial vacuolar pathology. Unlike G93A SOD1-related disease, the course was not accelerated by...

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Identifiers

PMID: 21692800
DOI: 10.1111/j.1471-4159.2011.07360.x
PMCID: PMC3155629

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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