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Article

Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Sept 2004

Kiaei Mahmoud, Bush Ashley I, Morrison Brett M, Morrison John H, Cherny Robert A, Volitakis Irene, Beal M Flint, Gordon Jon W

Abstract excerpt

Mutations in the Cu/Zn superoxide dismutase (SOD1) gene cause familial amyotrophic lateral sclerosis (FALS) by gain of an aberrant function that is not yet well understood. The role of Cu(2+) in mediating the toxicity of mutant SOD1 has been earnestly contested. We tested the in vivo effects of genetically induced copper deprivation on the ALS phenotype of transgenic mice expressing G86R mutant mouse SOD1, a...

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Identifiers

PMID: 15356208
DOI: 10.1523/JNEUROSCI.2000-04.2004
PMCID: PMC6729922

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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